American Board of Pathology (ABPath) Practice Test 2026 - Free Pathology Exam Practice Questions and Study Guide

Thyrotropin-releasing hormone (TRH) is the key regulator of the production of thyroid-stimulating hormone (TSH). TRH is produced in the hypothalamus and acts on the anterior pituitary gland to stimulate the synthesis and secretion of TSH. TSH, in turn, plays a critical role in regulating the function of the thyroid gland, promoting the production of thyroid hormones which are essential for metabolism, growth, and development.

The significance of TRH in this regulatory pathway highlights its role as a primary endocrine signal, ensuring that the levels of TSH and subsequently thyroid hormones remain balanced within the body. This feedback loop is crucial for maintaining homeostasis, particularly in response to the body's metabolic needs.