American Board of Pathology (ABPath) Practice Test 2026 - Free Pathology Exam Practice Questions and Study Guide

Autosomal dominant polycystic kidney disease (ADPKD) primarily impacts the kidneys, leading to the formation of numerous cysts. However, it can also affect various other organs, most notably the liver. In fact, hepatic cysts are commonly found in individuals with ADPKD, and these can be asymptomatic or lead to complications in some cases. The prevalence of liver involvement in these patients is significant, with estimates suggesting that up to 80% of individuals with ADPKD develop liver cysts over their lifetime.

In addition to the liver, the disease can also potentially impact the spleen, although splenic cysts are less common compared to hepatic cysts. Generally, autosomal dominant conditions can lead to extrarenal manifestations, but in the context of ADPKD, liver involvement is the most recognized, making this option particularly relevant to the question.

The other options list organs that either are less frequently associated with ADPKD or lack a strong direct association with the disease. For example, while the pancreas and gallbladder may have their own related pathologies, they are not the primary focus of ADPKD. Similarly, while adrenal glands may potentially develop cysts, it is the liver that has significant clinical